Table III.
Characteristics of the patients with congenital hypopituitarism and controls in the validation set.
| Characteristics | Congenital hypopituitarism, n=40 | Controls, n=40 | P-value |
|---|---|---|---|
| Basic information | |||
| Age, years | 26.49±3.42 | 25.08±3.56 | 0.143 |
| Height, cm | 166.7±8.71 | 171.5±6.34 | 0.093 |
| Weight, kg | 63.28±14.92 | 65.31±7.06 | 0.068 |
| BMI, kg/m2 | 23.10±4.19 | 22.23±2.31 | 0.768 |
| Thyroid function | |||
| FT3, pmol/l | 3.77 (2.57-5.07) | 4.19 (2.32-5.43) | 0.196 |
| FT4, pmol/l | 11.28 (6.96-16.92) | 12.45 (7.34-17.08) | 0.090 |
| TSH, µIU/l | 0.15 (0.00-4.42) | 1.53 (0.56-3.25) | <0.001 |
| Corticotropic function | |||
| Cortisol, µg/dl | 3.01 (0.13-19.13) | 13.69 (7.10-21.21) | <0.001 |
| ACTH, pg/ml | 20.54 (4.65-60.15) | 43.00 (20.00-55.00) | <0.001 |
| Gonadotropic function | |||
| LH, mIU/l | 0.18 (0.01-3.98) | 3.82 (1.27-8.26) | <0.0001 |
| FSH, µIU/ml | 0.72 (0.05-6.16) | 5.04 (1.45-10.36) | <0.0001 |
| PRL, ng/ml | 15.79 (1.63-54.57) | 8.32 (3.56-11.67) | <0.0001 |
| E2, pg/ml | 24.30 (20.00-68.90) | 23.00 (20.00-45.40) | 0.8898 |
| PROG, ng/ml | 0.10 (0.10-0.49) | 0.10 (0.10-0.89) | 0.1731 |
| TESTO, ng/ml | 2.59 (0.10-10.67) | 4.31 (2.25-7.02) | 0.0429 |
The data for basic information are presented as the mean ± standard deviation. All other data are presented as the median (range). ACTH, adrenocorticotropic hormone; BMI, body mass index; FT3, free thyroxine 3; FT4, free thyroxine 4; TSH, thyroid stimulating hormone; PRL, prolactin; PROG, progesterone; TESTO, testosterone; LH, luteinising hormone; FSH, follicle-stimulating hormone.