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. 2018 Oct 23;43(1):103–116. doi: 10.3892/ijmm.2018.3950

Figure 9.

Figure 9

Silencing the expression of Galectin-1 ameliorates liver fibrosis. (A) Hematoxylin and eosin staining results verified that mice in the sh-Galectin-1 group had a small amount of inflammatory cell infiltration (magnification, ×200). (B) Masson staining results verified that mice in the sh-Galectin-1 group had significantly decreased liver fibrosis (magnification, ×200). (C) Immunohistochemistry results verified that mice in the sh-Galectin-1 group had decreased positive expression for α-SMA and Desmin (magnification, ×200). (D) ELISA demonstrated that the expression levels of ALT, AST and Tbil were decreased, whereas that of ALB was increased by Galectin-1 gene silencing. (E) Western blot assay results demonstrated that Galectin-1 was expressed at a low level in the sh-Galectin-1 group;*P<0.05 vs. sh-NC group. α-SMA, α-smooth muscle actin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; TBil, total bilirubin; sh, short hairpin RNA; NC, negative control.