Table 1.
MicroRNA tumor suppressors and oncomirs proven or strongly assumed to be correlated with gemcitabine activity in mesothelioma.
| miRNA | Target(s) | Function | Expressiona |
|---|---|---|---|
| let-7b | Akt, Caspase 3, Twist, β-catenin | tumor suppressor | – |
| let-7c | ITGB3, MAP4K3 | tumor suppressor | lower in short survivors |
| let-7d | – | tumor suppressor | higher |
| miR-15/16 | Bcl-2, CCND1 | tumor suppressor | lower |
| miR-17-5p | Bim | oncomir | higher in short survivors |
| miR-21 | PDCD4, PTEN | oncomir | higher |
| miR-30 | FN1, vimentin, N-cadherin | oncomir | – |
| miR-34a | c-MET/Akt | tumor suppressor | lower |
| miR-34b | Bcl-2 | tumor suppressor | lower |
| miR-143 | IGF-1R | tumor suppressor | lower |
| miR-145 | OCT4 | tumor suppressor | lower |
| miR-148a | – | tumor suppressor | higher |
| miR-497 | FGF2, FGFR1 | tumor suppressor | lower |
a
Expression in mesothelioma when compared with non-malignant/benign samples or other tumors.