Table 3.
MicroRNA tumor suppressors and oncomirs in mesothelioma proven or assumed to be correlated with pemetrexed activity.
| miRNA | Target(s) | Function | Expressiona |
|---|---|---|---|
| let-7c | ITGB3, MAP4K3 | tumor suppressor | lower in short survivors |
| miR-15/16 | Bcl-2, CCND1 | tumor suppressor | lower |
| miR-21 | PDCD4, PTEN, mesothelin | oncomir | higher |
| miR-34a | c-MET/Akt | tumor suppressor | lower |
| miR-126 | – | tumor suppressor | lower |
| miR-145 | OCT4 | tumor suppressor | lower |
| miR-202 | MTHFD2 | tumor suppressor | – |
| miR-203 | DKK1 | tumor suppressor | lower |
| miR-210 | NUPR1, HTRA1, RGS10 | oncomir | higher in short survivors |
| miR-345 | MRP1 | tumor suppressor | higher |
| miR-379 | IL-18 | tumor suppressor | lower |
| miR-451 | PSMB8, MIF, ERCC1 | tumor suppressor | lower |
| miR-486 | ARHGAP5 | tumor suppressor | lower in short survivors |
| miR-494 | FZD4, SUFU | tumor suppressor | lower |
| miR-1281 | – | oncomir | higher |
a
Expression in mesothelioma when compared with non-malignant/benign samples or other tumors.