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. 2018 Nov 26;13(11):e0207921. doi: 10.1371/journal.pone.0207921

Table 5. Classes of psychotropic agents used (in %) according to sex; Campinas, Brazil, 2014–2015.

Classes of psychotropic agents according to ATC classification system Total Male sex Female sex p-value χ2
n %a %a %a
Antidepressants 154 38.2 25.5 44.3 0.0106*
 SSRIs1# 111 28.8 20.2 33.0 0.0756
 Tricyclic2 25 6.2 3.90 7.3 0.3195
 Others3 18 3.2 1.40 4.0 0.1556
Benzodiazepines 115 24.0 24.1 24.0 0.9930
 Clonazepam 60 13.0 15.3 11.8 0.4095
 Diazepam 29 6.0 6.8 5.7 0.7106
 Others4 26 5.0 2.0 6.5 0.0580
Anti-epileptics 56 15.4 21.2 12.6 0.1302
 Carbamazepine 20 5.2 5.8 5.0 0.8054
 Phenytoin 9 1.8 3.5 0.9 0.0610
 Others5 27 8.4 11.9 6.7 0.2377
Other psychotropic agents6 109 22.4 29.3 19.1 0.2743
 Antipsychotics 30 7.3 13.1 4.5 0.0707
 Anti-Parkinson’s 23 4.3 6.2 3.6 0.5763
 Others 56 10.7 9.9 11.1 0.6754

n: number of medications.

a Percentages weighted for sample design.

χ2 p-value from chi-squared test.

* statistically significant difference.

1 fluoxetine, citalopram, paroxetine, sertraline, escitalopram.

2 imipramine, clomipramine, amitriptyline, nortriptyline.

3 trazodone, mirtazapine, bupropion, venlafaxine, duloxetine, desvenlafaxine.

4 lorazepam, bromazepam, clobazam, alprazolam, cloxazolam, flunitrazepam, zolpidem.

5 phenobarbital, primidone, oxcarbazepine, valproic acid, lamotrigine, topiramate, gabapentin, pregabalin.

6 Opioid analgesics (morphine, codeine, tramadol); Anti-Parkinson’s (biperiden, levodopa, amantadine, pramipexole, selegiline, rasagiline, entacapone); Antipsychotics (levomepromazine, haloperidol, olanzapine, quetiapine, lithium, risperidone, aripiprazol); Anxiolytics (buspirone); Psychostimulants: (methylphenidate, piracetam); Anti-dementia (rivastigmine, galantamine, memantine).

# selective serotonin reuptake inhibitors.