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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Nat Biomed Eng. 2018 Nov 8;2(11):865–877. doi: 10.1038/s41551-018-0317-8

Fig. 1 ∣. Preferential renal accumulation of DONs enabled protection against AKI.

Fig. 1 ∣

a, Three different DONs (Rec-DON, Tri-DON and Tub-DON) showed selective kidney accumulation after intravenous injection. When applied to murine models of rhabdomyolysis-induced AKI, DONs can scavenge ROS and alleviate oxidative stress locally, protecting kidney structures and alleviating AKI. b, Schematic structures of the three DONs (top) and corresponding AFM images (bottom). Insets: single DON structures. Scale bars, 100 nm.