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. Author manuscript; available in PMC: 2018 Nov 27.
Published in final edited form as: Microsyst Nanoeng. 2015 Jun 29;1(1):15010. doi: 10.1038/micronano.2015.10

Figure 7.

Figure 7

Histology of tissue response to chronically implanted NEs. (a) and (b) immunohistochemically marked glial fibrillary acidic protein (GFAP) in the tissue that had been implanted with NEs for 16 weeks: (a) ECM-NEs, (b) PDMS-NEs; (c) average image intensities of immunohistochemically marked GFAP were computed up to a distance of 100 μm from the brain tissue–device interface. (d) Integrated image intensities of immunohistochemical markers for the reactive astrocyte responses were computed up to a distance of 100 μm from the brain tissue–NE interface. Significant differences observed between the ECM-NEs and PDMS-NEs in the integrated image intensities of immunohistochemical markers are represented by *, indicating p < 0.05.