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Illustration of adopted and simplified mPTP complex [53]. Increased mitochondrial oxidative stress primes CypD to bind with ANT (thiol oxidation-dependent), and VDAC-ANT complex causes mPTP opening. Increased activities of Sirt3 inhibit CypD-ANT bond and subsequently suppress mPTP opening. For detailed mPTP complex structure please refer to Rizwan, M. et al. [53]
