Table 3.
The domains of interest in the EMIF-AD 90+ Study
| Domain | Parameter | Procedure (measurement) | Schedule Amsterdam | Schedule Manchester |
|---|---|---|---|---|
| Cognitive reserve | Level of education | Interview | Home | Home |
| Cognitive activity | Cognitive abilities questionnaire | Home | Home | |
| Vascular comorbidity | Cholesterol level, hypertension, DM, stroke, AF | Blood collection | Hospital | WMIC |
| Medical history and medication use | Home | Home | ||
| Blood pressure | Hospital | CRF | ||
| Diagnostick/heart rate | Home | CRF | ||
| Ultrasound carotid artery | Hospital | CRF | ||
| Mood and sleep | Depressive symptoms | Geriatric Depression Scale | Home | Home |
| Sleep disorder | Berlin Questionnaire and MSQ | Home | Home | |
| Accelerometer (sleep quality) | Home | N/A | ||
| Sensory system | Visual acuity | ETDRS chart | Hospital | N/A |
| Retinal thickness | OCT | Hospital | N/A | |
| Auditory function | Digits-in-noise test | Home | N/A | |
| Olfactory function | Sniffin sticks | Hospital | N/A | |
| Physical performance and capacity | Physical performance | Grip strength | Home | CRF |
| Short Physical Performance Battery or 4-min walking test | Hospital | CRF | ||
| BIA (muscle mass) | Hospital | N/A | ||
| Physical activity | Accelerometer | Home | N/A | |
| Genetics | APOEε4 and APOEε2 | Blood collection | Hospital | WMIC |
| Hallmarks of ageing | Level of inflammation markers | Blood collection (i.a. PBMCs) | Hospital | WMIC |
| Level of senescence markers | Skin biopsy (senescence markers p16, p53 and telomere associated foci) | Hospital | N/A | |
| Nutritional status | BIA | Hospital | N/A | |
| Blood collection | Hospital | CRF | ||
| BMI | Hospital | CRF | ||
| MNA | Home | N/A | ||
| Markers of neurodegeneration | Aβ1–42 and tau in CSF and blood | CSF collection Blood collection |
Hospital | N/A |
| Amyloid PET scan | Amyloid PET scan | Hospital | WMIC | |
| Brain atrophy | Brain MRI scan or brain CT scan | Hospital | CRF | |
| WMH | Brain MRI scan or brain CT scan | Hospital | CRF | |
| White matter integrity | Brain MRI scan | Hospital | N/A | |
| Brain connectivity | Brain MRI scan | Hospital | CRF | |
| MEG | Hospital | N/A |
Aβ Amyloid β, AD Alzheimer’s disease, AF atrial fibrillation, APOE Apolipoprotein E, BIA Bioelectrical impedance analysis, BMI Body Mass Index, CRF Clinical Research Facility, CT Computerized Tomography, CSF cerebrospinal fluid, DM diabetes mellitus, ETDRS Early Treatment Diabetic Retinopathy Study, MEG magnetoencephalography, MNA Mini Nutritional Assessment, MRI Magnetic Resonance Imaging, MSQ Mayo Sleep Questionnaire, N/A not applicable, OCT Optical Coherence Tomography, PBMCs Peripheral Blood Mononuclear Cells, PET positron emission tomography, PLAD Project of Longevity and Aging in Dujangyan, WMH white matter hyperintensities, WMIC Wolfson Molecular Imaging Centre