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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Biochem Pharmacol. 2018 Nov 2;158:298–304. doi: 10.1016/j.bcp.2018.10.035

Figure 2. K562 cells pre-loaded with a phosphoantigen prodrug stimulate Vγ9Vδ2 T cell interferon-γ production more potently than a natural BTN3A1 ligand or a bisphosphonate drug.

Figure 2.

A) Timeline for compound exposure to target cells and target cell exposure to effector Vγ9Vδ2 T cells. B) Compounds in this study act as either direct BTN3A1 ligands, prodrugs requiring cellular metabolic activation, or indirect bisphosphonates (BPs) which require FDPS inhibition. C) Stimulation of Vγ9Vδ2 T cell interferon-γ by K562 cells pre-exposed to compounds for equivalent time (60 minutes) and concentration (1 μM). Bars represent means and standard deviations of three independent experiments (n=3). Statistical significance was determined by oneway ANOVA with Tukey’s post-hoc analysis. *p < 0.05 versus untreated control.