Fig. 2.

Effect of APOE allele status in cognitively normal controls. (A) Within the cognitively normal individuals, carriers of APOE-ε4 had a faster rate of decline (Blue ⋄, high slope = −0.53) in the parahippocampal regions compared with the noncarriers (Pink •, slope = 0.14). (B) Amyloid-negative ε4 carrier controls had higher cortical thickness in the inferior parietal, middle temporal, and precuneal regions compared with ε4 noncarriers. ∗ Denotes mean values for each group. Abbreviation: APOE, apolipoprotein E.