Table 1.
Temporal regions are significantly smaller in the amnestic phenotype compared with cognitively normal controls
| Regions | Effect size | P value | FDR significance | |
| Cognitively normal older adults versus mildly amnestic phenotype individuals | ||||
| Medial orbitofrontal | 0.23 | .13 | ||
| Middle temporal | 0.31 | .009 | * | |
| Parahippocampal | 0.38 | .005 | * | |
| Hippocampus | 0.08 | .05 | ||
| Inferior parietal | 0.16 | .21 | ||
| Posterior cingulate | 0.16 | .42 | ||
| Precuneus | 0.27 | .01 | ||
| r (cognitively normal) |
r (amnestic MCI phenotype) |
P value |
FDR significance |
|
| Age interactions | ||||
| Medial orbitofrontal | 0.07 | 0.07 | .99 | |
| Middle temporal | −0.19 | −0.16 | .99 | |
| Parahippocampal | −0.09 | −0.16 | .52 | |
| Hippocampus | −0.27 | −0.49 | .007 | * |
| Inferior parietal | −0.3 | −0.3 | .75 | |
| Posterior cingulate | −0.01 | −0.13 | .37 | |
| Precuneus | −0.37 | −0.5 | .13 | |
Abbreviations: FDR, false discovery rate; MCI, mild cognitive impairment.
NOTE. Bold values denote significance at P = .05 value that is uncorrected using FDR. ∗ Indicates values that are significant after correcting for multiple comparisons using FDR.