Table 2.

No significant difference between APOE-ε4 carriers and noncarriers within the cognitively normal individuals, and APOE-ε4 carriers within the aMCI phenotype showed cortical thinning in multiple default mode regions compared with noncarriers

Regions	Effect size	P value	FDR significance
Controls, APOE-ε4 carriers versus noncarriers
Medial orbitofrontal	0.08	.71
Middle temporal	0.20	.16
Parahippocampal	0.00	.83
Hippocampus	0.11	.69
Inferior parietal	0.50	.01
Posterior cingulate	0.23	.26
Precuneus	0.23	.08
	r (noncarriers)	r (carriers)	P value	FDR significance
Age interactions
Medial orbitofrontal	0.13	−0.02	.35
Middle temporal	−0.06	−0.38	.03
Parahippocampal	0.14	−0.51	.0004	*
Hippocampus	−0.18	−0.48	.18
Inferior parietal	−0.21	−0.46	.75
Posterior cingulate	0.05	−0.16	.28
Precuneus	−0.29	−0.53	.17
	Effect size	P value	FDR significance
aMCI, APOE-ε4 carriers versus noncarriers
Medial orbitofrontal	0.28	.3
Middle temporal	0.57	.009	*
Parahippocampal	0.00	.87
Hippocampus	0.03	.79
Inferior parietal	1.00	.0001	*
Posterior cingulate	0.60	.03
Precuneus	0.84	.0002	*
	r (noncarriers)	r (carriers)	P value	FDR significance
Age interactions
Medial orbitofrontal	−0.02	0.31	.16
Middle temporal	−0.09	−0.23	.33
Parahippocampal	−0.09	−0.34	.34
Hippocampus	−0.47	−0.56	.53
Inferior parietal	−0.26	−0.3	.54
Posterior cingulate	−0.06	−0.25	.54
Precuneus	−0.45	−0.59	.32

Abbreviations: aMCI, amnestic mild cognitive impairment; APOE, apolipoprotein; FDR, false discovery rate.

NOTE. Bold values denote significance at P = .05 value that is uncorrected using FDR. ∗ Indicates values that are significant after correcting for multiple comparisons using FDR.