. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Am J Ophthalmol. 2018 Oct 9;196:197–207. doi: 10.1016/j.ajo.2018.10.005

Table 4.

Characteristics of 44 eyes with a definite graft rejection episode by graft failure status at 3 years in the Cornea Preservation Time Study

	Failed (N=12)	Did Not Fail (N=32)
*Selected Donor/Recipient Factors*
*n (%)*
Recipient Diagnosis
FECD	10 (24%)	32 (76%)
PACE (without FECD)	2 (100%)	0 (0%)
Preservation Time Group
0–7 Days	4 (18%)	18 (82%)
8–14 Days	8 (36%)	14 (64%)
Donor History of Diabetes
No	7 (25%)	21 (75%)
Yes	5 (31%)	11 (69%)
*mean ± SD*
Recipient Age (years)	67 ± 8	65 ± 10
Screening ECD (EB determined - cells/mm²)	2834 ± 380	2713±291
Pre-Operative ECD (EB determined - cells/mm²)	2799 ± 325	2709 ± 260
Pre-Operative ECD (CIARC determined - cells/mm²)^a	2769 ± 423	2667 ± 324
*median (IQR)*
ECD before rejection (cells/mm²)^a,b	2000 (962, 2726)	2443 (1830, 2765)
ECD after rejection (cells/mm²)^c	665 (481, 772)	1453 (984, 2303)
*mean ± SD*
Difference in ECD after and before rejection (cells/mm²)^a,b,c	−1356 ± 984	−658 ± 632
*median (IQR)*
Days between ECD before and after rejection^a,b,c	175 (173, 716)	321 (196, 378)
Days from last ECD before rejection to rejection^a,b	147 (111, 267)	138 (82, 309)

^a.

Excludes one eye that did not fail. This eye did not have a CIARC determined pre-operative ECD.

^b.

For eyes with no ECD measurements at follow-up prior to rejection, the baseline value was used as ECD prior to rejection, and the first visit time was used as the time of measurement. One eye did not have a baseline ECD value or any ECD measurements before rejection. This eye was excluded from tabulations involving ECD before rejection.

^c.

Nine eyes that failed and two eyes that did not fail did not have any ECD screenings after rejection. One eye that did not fail had an ECD screening after rejection but no screening before rejection. Only eyes with an ECD screening available before and after rejection were included in the tabulations of differences between before and after rejection. The difference in the number of days from lasted screening before rejection to the date of rejection could not be calculated for the eye with no measurement prior to rejection.

PACE = pseudophakic/aphakic corneal edema; FECD = Fuchs endothelial corneal dystrophy; ECD = endothelial cell density; EB = eye bank; CIARC = Cornea Image Analysis Reading Center