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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Leukoc Biol. 2018 Aug 21;104(6):1253–1261. doi: 10.1002/JLB.5TA0318-110RRR

FIGURE 4. Migration patterns of neutrophils from patients.

FIGURE 4

(A) An over-extended leading edge and an elongated tail are common among neutrophils from kidney-transplant patients receiving immune-suppressing treatments. The green arrows indicate the tail of the neutrophil. The red arrow indicates the leading edge of the neutrophil. (B) Nuclear morphology of oscillating neutrophils from ICU patients shows frequent cluster to string to cluster transformation. The scale bar is 50 μm. (C) Larger numbers of neutrophils display arrest, oscillation, and retrotaxis patterns in patients (transplant, ICU, and neonates) compared to the healthy control (percentages of P, A, O, R patterns are presented in blue, red, green, and yellow, respectively). (D) The cross-section for migration patterns transition for neutrophils from transplant patients is comparable to that of controls. The cross-section is significantly larger for ICU patients and neonatal patients