Table 4.

Group effects on radial diffusivity (RD) and axial diffusivity (λ1) for each region of interest at p < 0.05. There were significant increases in RD in the left ALIC in the Chronic Kidney Disease (CKD) group and in the left ALIC and left optic radiation in the transplant group compared to control group. There was a significant decrease in RD the left PLIC in the CKD group compared to the control group. There was a significant decrease in (λ1) in the CKD group in the right PLIC compared to control group. (ALIC = Anterior limb of the internal capsule, PLIC = Posterior limb of the internal capsule).

Brain Region	Group	Mean difference from controls	95% CI		p	Mean difference from controls	95% CI		p
		Radial diffusivity (RD)				Axial diffusivity (λ1)
Left ALIC	CKD	0.064	0.025	0.104	0.002*	−0.046	−0.109	0.017	0.2
	Transplant	0.099	0.043	0.155	0.001*	0.013	−0.078	0.103	0.8
Right ALIC	CKD	−0.002	−0.054	0.049	0.9	−0.048	−0.124	0.028	0.2
	Transplant	0.006	−0.037	0.112	0.3	−0.05	−0.159	0.060	0.4
Left PLIC	CKD	−0.053	−0.097	−0.001	0.02*	−0.053	−0.112	0.006	0.08
	Transplant	0.005	−0.058	0.067	0.9	−0.067	−0.153	0.018	0.1
Right PLIC	CKD	−0.017	−0.053	0.020	0.4	−0.078	−0.142	−0.014	0.02*
	Transplant	0.034	−0.019	0.087	0.2	−0.070	−0.162	0.022	0.1
Left Optic	CKD	−0.028	−0.087	0.032	0.4	−0.012	−0.095	0.072	0.8
Radiation	Transplant	0.093	0.007	0.178	0.03*	0.071	−0.049	0.190	0.2
Right Optic	CKD	0.020	−0.047	0.087	0.5	−0.062	−0.132	0.009	0.08
Radiation	Transplant	−0.000	−0.078	0.114	0.7	−0.000	−0.124	0.079	0.7