Table 3.

Estimated rate of change (and 95 percent confidence intervals) in Bruch’s membrane opening minimum rim width (MRW) for African descent and European descent individuals within diagnostic groups. Values shown are adjusted for age, mean IOP during follow-up, CCT, axial length, and Bruch’s membrane opening area.

	Healthy eyes				Glaucoma suspect eyes				Glaucoma eyes
	AD	ED	Total	P-value**	AD	ED	Total	P-value**	AD	ED	Total	P-value**	P-value***
Global MRW(μm/year)	−1.68 (−2.8, −0.08)*	−1.55 (−2.6, −0.01)*	−1.61 (−2.7, −0.03)	0.11	−2.2 (−3.8, −0.1)*	−1.82 (−2.7, −0.05)*	−2.01 (−3.3, −0.06)*	0.03	−2.87 (−4.3, −0.2)*	−2.91 (−4.5, −0.03)*	−2.89 (−4.4, −0.11)*	0.21	<0.001
Nasal MRW (μm/year)	−0.06 (−2.1, 1.3)	0.04 (−3.1, 2.8)	0.01 (−2.1, 27)	0.17	−0.17 (−2.5, 1.8)	0.31 (−1.7, 2.5)	0.07 (−2.1, 2.2)	0.15	−1.06 (−2.5, −0.5)*	−1.14 (−3.2, −0.18)*	−1.1 (−2,92, −0.32)*	0.18	<0.001
Temporal MRW (μm/year)	−1.88 (−2.9, −0.3)*	−1.95 (−2.4, −0.05)*	−1.91 (−2.5, −0.07)	0.22	−2.61 (−3.7, −0.1)*	−2.15 (−2.3, −0.11)*	−2.38 (−3.1,−0.1)*	0.01	−2.77 (−4.2, −0.1)*	−2.29 (−3.29, −0.15)*	−2.53 (−3.46, −0.12)*	0.06	<0.001
Inferior MRW (μm/year)	−1.44 (−2.3, −0.4)*	−1.53 (−2.4, −0.03)*	−1.48 (−2.4, −0.21)	0.07	−1.99 (−2.4, −0.2)*	−1.61 (−2.1, −0.05)*	−1.8 (−2.2, −0.12)*	0.03	−3.14 (−4.7, −1.2)*	−3.23 (−4.14, −0.23)*	−3.18 (−4.37, −0.66)*	0.35	<0.001
Superior MRW (μm/year)	−0.55 (−1.5, 1.4)	−0.95 (−1.3, 1.2)*	−0.75 (−1.4, 1.3)	0.22	−0.71 (−1.2, 1.6)*	−0.32 (−1.5, 1.4)	−0.52 (−1.3, 1.6)	0.26	−1.77 (−2.85, −0.14)*	−1.85 (−2.23, −0.7)*	−1.79 (−2.61, −0.32)*	0.12	<0.001

Abbreviations: MRW, minimum rim width

^*significant slope (P-value < 0.05),

^**P-value evaluates differences in the mean rate of change between AD and ED eyes,

^***(ANOVA) P-values between “total” mean values among diagnostic groups (without respect to race).