Table 5.

Estimated rate of change (and 95 percent confidence intervals) in retinal nerve fiber layer (RNFL) thickness for African descent and European descent individuals within diagnostic groups. Values shown are adjusted for age, mean IOP during follow-up, CCT, axial length, and Bruch’s membrane opening area.

	Healthy eys				Glaucoma suspect eyes				Glaucoma eyes				ANOVA
	AD	ED	Total	P- Value**	AD	ED	Total	P- Value**	AD	ED	Total	P- Value**	P- value***
Global RNFL (um/year)	−0.51 (−0.7,−0.1) *	−0.44 (−0.68,−0.01)	−0.44 (−0.68,−0.01) *	0.35	−0.75 (−0.97,−0.52) *	−0.64 (−0.74,−0.35) *	−0.75 (−0.97,−0.52)	0.75	−0.94 (−1.2,−0.6) *	−0.89 (−1.19,−0.54)	−0.91 (−1.19,−0.52) *	0.4	0.02
Nasal RNFL (um/year)	−0.49 (−0.6,−0.24) *	−0.35 (−0.51,−0.07)	−0.42 (−0.55,−0.12) *	0.3	−0.59 (−0.92,−0.24) *	−0.55 (−0.88,−0.02) *	−0.57 (−0.91,−0.13)	0.9	−0.88 (−1.05,−0.61) *	−0.91 (−1.12,−0.55)	−0.9 −1.11,−0.57) *	0.27	0.01
Temporal RNFL (um/year)	−0.38 (−0.6,−0.06) *	−0.31 (−0.41,−0.01)	−0.34 (−0.52,−0.03) *	0.8	−0.56 (−0.78,−0.34) *	−0.49 (−0.82,−0.18) *	−0.52 (−0.81,−0.21)	0.58	−0.97 (−1.1,−0.46) *	−0.99 (−1.09,−0.35)	−0.98 (−1.09,−0.37) *	0.81	0.02
Inferior RNFL (um/year)	−0.41 (−0.56,−0.02) *	−0.38 (−0.52,−0.01)	−0.39 (−0.54,−0.01) *	0.39	−0.51 (−0.72,−0.19) *	−0.57 (−0.79,−0.34) *	−0.54 −0.74,−0.22)	0.27	−0.69 (−0.92,−0.42) *	−0.71 (−1.04,−0.41)	−0.70 (−0.89,−0.45) *	0.64	0.01
Superior RNFL (um/year)	−0.35 (−0.52,−0.12) *	−0.39 (−0.61,−0.09)	−0.37 (−0.57,−0.11) *	0.33	−0.58 (−0.75,−0.15) *	−0.53 (−0.76,−0.24) *	−0.55 (−0.76,−0.21)	0.16	−0.97 (−1.35,−0.54) *	−1.05 (−1.28,−0.65)	−1.01 (−1.29,−0.62) *	0.38	0.004

Abbreviations: RNFL, retinal nerve fiber layer thickness.

^*significant slope (P-value < 0.05),

^**P-value evaluates differences in the mean rate of change between AD and ED eyes,

^***(ANOVA) P-values between “total” mean values among diagnostic groups (without respect to race).