Table 1.

Suggested indications, contraindications and monitoring for use of CGRP monoclonal antibodies in children and adolescents with migraine

Indications	Contraindications	Monitoring
≥8 headache days per month PedMIDAS score ≥30 Failure of ≥2 preventive therapies (pharmacologic, nutraceutical, and/or non-pharmacologic) Post-pubertal adolescent, or pre-pubertal child in selected cases	Disturbed blood-brain barrier (e.g. recent history of meningitis, recent neurosurgery) Severe cardiovascular disease, stroke Pregnancy, planned pregnancy or breast-feeding	Pubertal status Bone health, consider checking Vitamin D status Linear growth Weight/BMI Infections Pregnancy status

BMI=body-mass index