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. Author manuscript; available in PMC: 2019 Nov 27.
Published in final edited form as: Chembiochem. 2018 May 27:10.1002/cbic.201800285. doi: 10.1002/cbic.201800285

Scheme 1.

Scheme 1.

Structures and gene clusters of four terpenoids found within the 66 putative diterpenoid producers. A) The TNLs were discovered in this study; PLA, BRA, and LON (KS-505a) were known. The absolute stereochemistries of BRA and TNL were determined; only the relative stereochemistries of PLA and LON were reported. B) Genetic organizations of the tnl (CB03234), tnl’ (CB03238), pla, bra, and Ion biosynthetic gene clusters, highlighting the genetic and potential structural diversities found within this family natural products. Genes are colored based upon their annotated Pfam IDs (Tables S3–S6). GenBank accession numbers for tnl CB03234 (BK010469) and tnl CB03238 (BK010470).