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. 2018 Nov 27;6:131. doi: 10.1186/s40425-018-0450-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — MCPyV-oncoprotein antibody titers over the course of anti-PD-1 therapy. 15 of 17 (88%) patients with VP-MCC tumors produced antibodies specific for MCPyV small T oncoprotein while no VN-MCC patients produced antibodies. MCPyV-oncoprotein antibody titer was tracked over time in seropositive individuals with available post-treatment serum samples (n = 13). Titers are plotted as percent change from baseline (100%). a) Patients with a complete response experienced a decrease in titer (n = 3). b) Among partial responders (n = 8), titer initially decreased over time in 7 of 8 patients. Two patients subsequently recurred (denoted by *); clinical detection of recurrence was preceded by a rise in titer in both cases