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. 2018 Nov 27;6:131. doi: 10.1186/s40425-018-0450-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Comparison of T cell receptor clonality by viral status and response to anti-PD-1. a) TCR clonality is significantly higher in patients with VP-MCCs compared to those with VN-MCCs (p = 0.0001 by Mann-Whitney test). b) TCR clonality is not associated with response to pembrolizumab (p = 0.2636 by Mann-Whitney test). This observation remains true when comparing clonality among responding versus non-responding patients whose tumors are virus-positive (virus(+) = open circles; virus(−) = black squares)