Table 5. Association between selected P450 gene SNP frequency and deltamethrin resistance in natural Aedes albopictus populations.
| Gene | Transcript ID | Amino acid change | Phenotype | N | Genotypes | Odds ratio (95%CI) | P | ||
|---|---|---|---|---|---|---|---|---|---|
| annotation | Homozygous mutation | Heterozygous mutation | Homozygous wild | ||||||
| CYP6A8 | CCG018947.1 | Arg226Ser | R | 43 | 7 | 6 | 30 | 19.09 (2.49–147) | < 0.0001 |
| S | 32 | 0 | 1 | 31 | |||||
| Asp279Gly | R | 65 | 5 | 18 | 42 | 1.84 (0.75–4.52) | 0.178 | ||
| S | 27 | 0 | 7 | 20 | |||||
| CYP9B2 | CCG006037.1 | Pro175Gln | R | 63 | 20 | 11 | 32 | 2.95 (1.43–6.06) | <0.005 |
| S | 32 | 4 | 4 | 24 | |||||
| CYP9B2 | CCG006695.1 | His877Tyr | R | 41 | 26 | 9 | 6 | 5.05 (2.38–10.7) | < 0.0001 |
| S | 26 | 8 | 3 | 15 | |||||
| CYP6A8 | CCG015439.1 | Met120Ile | R | 51 | 4 | 2 | 45 | 6.85 (0.86–54.8) | 0.037 |
| S | 32 | 0 | 1 | 31 | |||||
| CYP9B1 | CCG006036.1 | Leu282Arg | R | 57 | 2 | 3 | 52 | NA | NA |
| S | 32 | 0 | 0 | 32 | |||||
| CYP1A1 | CCG011108.1 | Cys212Ser | R | 62 | 55 | 5 | 2 | 55.37 (21.97–140) | <0.0001 |
| S | 32 | 5 | 2 | 25 | |||||
NA: not applicable. Odds ratio measures the association between SNP genotype and resistance.