Table 1.

Inclusion criteria

Inclusion criteria

• Liver metastases considered not suitable for surgery, because of being technically or medically inoperable or because of patient refusal;  • Maximum tumor diameter less than 6 cm;  • No more than 3 liver lesions;  • Normal liver volume greater than 1000 cm3;  • No evidence of progressive or untreated gross disease outside of the liver;  • No prior radiation therapy to the targeted area;  • Adequate liver function, defined as total bilirubin < 3 mg/dL, albumin > 2.5 g/dL, normal prothrombin time (PT)/partial thromboplastin time (PTT) unless on anticoagulants, and serum levels of aspartate aminotransferase (AST) and alanine amynotransferase (ALT) less than 3 times the upper limit of normal;  • No concurrent chemotherapy allowed, either within 14 days before SBRT or until the first revaluation thereafter;  • No active connective tissue disorders;  • Karnofsky Performance Status 70;  • Minimum age 18 years;  • Written informed consent.