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. 2018 Nov 26;19:205. doi: 10.1186/s13059-018-1581-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Unequivocal identification of low-affinity endogenous receptor-ligand interactions using CRISPRa. Transformed gene-level enrichment P values are plotted against rank-ordered genes for receptor CRISPRa cell selections performed using the ectodomains of EFNA1 (a), CD55 (b), CTLA4 (c), and rat Cd200r (d). Screens were conducted in duplicate