. 2018 Jul 20;7(2):247–262. doi: 10.1007/s40123-018-0140-z

Table 1.

Rate of resolution, rate of recurrence, and toxicity of interferon-α2b used in primary immunotherapy for ocular surface squamous neoplasia

Authors	Year of publication	Study design	Eyes (n)	Drug delivery	Treatment duration	Duration of follow-up (months)	Recurrence rate (%)	Complete recurrence rate (%)	Time to resolution	Previous treatment	Side effects
Singh et al. [123]	2018	Prospective	6	Topical	24 weeks	3.38	0	100	16 weeks	MMC	Foreign body sensation, follicular conjunctivitis
Chaugule et al. [122]	2018	Retrospective	5	Topical	3 months	8.8	0	100	3 months	None	Irritation, burning, dry eye
Pujari et al. [160]	2018	Case report	1	Topical	N/A	12	0	100	5 weeks	None	N/A
Meel et al. [148]	2017	Retrospective	26	Topical	N/A	16.15	N/A	65.38	8 weeks	MMC, excision biopsy	N/A
Meel et al. [148]	2017	Retrospective	13	Local	N/A	16.15	N/A	69.23	6 weeks	MMC, excision biopsy	N/A
Kusumesh et al. [121]	2017	Retrospective	26	Topical	N/A	22.2	3.85	89	3.1 months	None	Conjunctival hyperemia, burning sensation
Kaliki et al. [69]	2016	Retrospective	9	Topical	6 cycles^a	9	0	92	3 cycles^a	None	Conjunctival hyperemia
Kaliki et al. [69]	2016	Retrospective	13	Local and topical	7 cycles^b	9	0	92	4 cycles^b	None	Conjunctival hyperemia, flu-like syndrome
Kusumesh et al. [119]	2015	Retrospective	24	Topical	3.25 months	18.81	0	91.6	3.25 months	None	Conjunctival congestion, spontaneous intra-tumoral bleeding, foreign body sensation
Zarei-Ghanavati et al. [124]	2014	Prospective	5	Topical	8 weeks	10.2	0	100	8 weeks	One eye had excision + cryotherapy	None
Shah et al. [132]	2012	Retrospective	20	Topical	11 months	12	4	83	6 months	Excisional biopsy (39%), cryotherapy (9%), topical MMC (4%), topical interferon alpha-2b(13%)	Conjunctival hyperemia, follicular hypertrophy, giant papillary conjunctivitis, irritation, corneal epithelial defect, flu-like syndrome
Karp et al. [117]	2010	Retrospective	5	Local	6.6 cycles^c	30.64	20	80	3.49 months	None	Local irritation, flu-like syndrome
Karp et al. [117]	2010	Retrospective	10	Local and topical	5.9 cycles^c	84.06	0	90	1.89 months	None	Local irritation, flu-like syndrome

MMC Mitomycin C, N/A:not assessed

^aTopical interferon (INF)-α2b, four times/daily for 1 month

^bMonthly IFN-α2b injections

^cIFN-α2b injections, three times weekly initially, then weekly