Table 1. Included prospective randomized trial characteristics.

The 1st author, year	Intervention	Control	Participant country	Trial design	No. randomized	No. allocated intervention	No. allocated control	Procedures	Incision
Allen, 2004	Progel (biodegradable polymeric sealant, human serum albumin-USP)	Standard care	USA	Multi-center, open-label, stratified group	161	103	58	Wedge, segmentectomy, lobectomy, bilobectomy, LVRS, decortication	Open
Anegg, 2006	TachoSil (equine collagen patch coated with human fibrinogen-thrombin)	Standard care	Austria	Single-center, open-label, parallel group	152	75	77	Segmentectomy, lobectomy	Open
Belcher, 2010	Vivostat (autologous fibrin sealant)	BioGlue (mixture of bovine serum albumin and glutaraldehyde)	UK	Single-center, single-blind, parallel group	103	53	50	Wedge, segmentectomy, lobectomy, bilobectomy	NR
Cardillo, 2012	Fibrin sealant	Standard care	Italy	Multi-centre, open-label, parallel group	185	91	94	Segmentectomy, lobectomy, other	Open
Belboul, 2004	Vivostat (autologous fibrin sealant)	Standard care	Sweden	Single-center, open-label, parallel group	40	20	20	Lobectomy	Open
D’Andrilli, 2009	CoSeal (synthetic polyethylene glycol matrix)	Standard care	Italy	Single-center, open-label, parallel group	203	102	101	Wedge, segmentectomy, lobectomy, bilobectomy, sleeve lobectomy	Open
De Leyn, 2011	PleuraSeal (synthetic hydrogel tissue sealant)	Standard care	Belgium, Austria, The Netherlands, UK, Switzerland	Multi-centre, open-label, parallel group	121	63	59	Segmentectomy, lobectomy	Open
Fabian, 2003	HemaMyst fibrin glue	Standard care	USA	Single-center, double-blind, parallel group	100	50	50	Wedge, segmentectomy, lobectomy, bilobectomy	Open
Filosso, 2012	TachoSil (equine collagen patch coated with human fibrinogen-thrombin)	Standard care in re-do surgery	Italy	Single-center, open-label, parallel group	24	13	11	Completion lobectomy	Open
Gonfiotti, 2011	Fibrin sealant	Standard care	Italy	Multi-centre, open-label, parallel group	185	91	94	Segmentectomy, lobectomy	Open
Kýlýç, 2011	Tisseal (homologous fibrin sealant)	Vivostat (autologous fibrin sealant)	Turkey	Single-center, open-label, parallel group	80	40	40	Wedge, lobectomy	Open n=33; VATS n=24
Lang, 2004	TachoComb (fleece bound fibrin glue sealant)	Standard care	Austria, Hungary, Germany, Sweden	Multi-centre, open-label, parallel group	189	96	93	Lobectomy	Open
Lequaglie, 2012	CoSeal (synthetic polyethylene glycol matrix)	Standard care	Italy	Single-center, open-label, parallel group	222	111	111	Wedge, segmentectomy, lobectomy, bilobectomy, decortication	NR
Marta, 2010	TachoSil (equine collagen patch coated with human fibrinogen-thrombin)	Standard care	Germany, Italy, Austria, Belgium, Denmark, Hungary, Sweden, Switzerland	Multi-centre, open-label, parallel group	299	148	151	Lobectomy, bilobectomy	Open
Moser, 2008	Vivostat (autologous fibrin sealant)	Standard care	Switzerland	Single-center, double-blind, parallel group	50	25	25	Bilateral LVRS	VATS
Porte, 2001	Synthetic surgical lung sealant	Standard care	—	Single-center, open-label, parallel group	124	62	62	Lobectomy, bilobectomy	Open
Rena, 2009	TachoSil (equine collagen patch coated with human fibrinogen-thrombin)	Standard care	Italy	Single-center, open-label, parallel group	60	30	30	Lobectomy	Open
Tan, 2011	CoSeal (synthetic polyethylene glycol matrix)	Standard care	UK	Single-center, single-blind, parallel group	121	61	60	Lobectomy, bilobectomy	Open
Tansley, 2006	BioGlue (mixture of bovine serum albumin and glutaraldehyde)	Standard care	UK	Single-center, single-blind, parallel group	52	25	27	Segmentectomy, lobectomy, other	Open
Wain, 2001	Synthetic, bioresorbable surgical sealant; water soluble polyethylene glycol-based gel	Standard care	USA	Multi-centre, open-label, parallel group	172	117	55	Wedge, segmentectomy, lobectomy	Open
Wong, 1997	Tisseal (homologous fibrin sealant)	Standard care	UK	Single-center, open-label, parallel group	66	33	33	Segmentectomy, lobectomy, decortication	Open

No., number; LVRS, lung volume reduction surgery; NR, not reported; VATS, video-assisted thoracic surgery.