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. 2018 Nov 27;8:17418. doi: 10.1038/s41598-018-35603-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tukey box plot showing distribution of beta values for (A) a probe where the SNP is driving the methylation values and (B) the top LTA site from this study. The box plot shows the data within the interquartile range and the median is represented by a solid black line. Whiskers show maximum and minimum values. Grey bars indicate region for each genotype (homozygous allele 1 (1/1), heterozygous (1/2), and homozygous allele 2 (2/2)). Each point represents either an individual control (blue) or MS patients (red). Y axis shows β values.