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. 2018 Nov 27;9:4843. doi: 10.1038/s41467-018-06937-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Excessive 5HT and receptor imbalance causes ipsilateral tonic activity. a–f Tonic diaEMG activity following a 3 or b 5 weeks conditioning. c–f Representative CTAs of ipsilateral (coloured) and contralateral (grey) activity for mean inspiration (orange) and expiration (green) where ±SEM is shown for both inspiration (yellow) and expiration (light green). IH for c, d 3 or e, f 5 weeks (n = 6, see Fig. 5). g–l Intensity readings for g 5HT, h 5HT2c/a and l representative images at the ipsilateral C4 PMP utilizing i+k NeuN (red) and 5HT (green) or j+l 5HT2c/a (green). Graphs show mean ± SEM. Data grouped on ipsilateral hemidiaphragm activity: non-responders (circle; n = 1/2), normal activity (square; n = 1/2), tonic (triangle; n = 2). m, n Tonic activity following m 5HT (n = 7) and n 5HT2c/a antagonist (n = 6) application. CTAs of ipsilateral (coloured) and contralateral (grey) activity for mean inspiration (orange) and expiration (green) where ±SEM is shown for both inspiration (yellow) and expiration (light green) of pharmacologically induced and removed tonic activity. Panels recorded in the same animal. For all EMG or graph panels: animals were treated with ChABC+IH (blue)