Table 1.
List of contrast agents applied in this in vitro study
| Imaging system | Chemical name | Trade name (manufacturer) | Structure, ionicity | Initial concentration | Osmolality (mOsm/kg H2O) | Viscosity (mPa·s, 37 °C) | Clearance |
|---|---|---|---|---|---|---|---|
| MRI | Gadobutrol | Gadovist (Bayer Vital, Leverkusen, Germany) | Macrocyclic, nonionic | 1.0 mmol/mL | 1603 | 5.0 | Renal |
| MRI | Gadoterate meglumine | Dotarem (Guerbet, Roissy, France) | Macrocyclic, ionic | 0.5 mmol/mL | 1350 | 2.0 | Renal |
| MRI | Gadodiamide | Omniscan (General Electric Healthcare Buchler, Braunschweig Germany) | Linear, nonionic | 0.5 mmol/mL | 780 | 1.4 | Renal |
| MRI | Gadopentetate dimeglumine | Magnograf (Jenapharm, Jena, Germany) | Linear, ionic | 0.5 mmol/mL | 1960 | 2.9 | Renal |
| MRI | Gadoxetate | Primovist (Bayer Pharma, Berlin, Germany) | Linear, ionic | 0.25 mmol/mL | 688 | 1.2 | 50% hepatic, 50% renal |
| CT | Iomeprol | Imeron 300 M (Bracco Imaging, Konstanz, Germany) | Monomeric, nonionic | 300 mg iodine/mL | 521 | 2.9 | Renal |
| CT | Iopromide | Ultravist 300 (Bayer Vital, Leverkusen, Germany) | Monomeric, nonionic | 300 mg iodine/mL | 590 | 4.7 | Renal |
MRI magnetic resonance imaging, CT computed tomography