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. 2017 May 4;8(5):e2766. doi: 10.1038/cddis.2017.165

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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MDIG promotes migration and invasion of HCC cells. (a) Stably overexpressed MDIG with lentiviral vector (pWPXL) promotes in vitro migration of MHCC-LM3, MHCC-97L and SK-Hep1 cells. Quantitative data are presented (original magnification: × 100). (b) Ectopic MDIG expression promotes in vitro invasion of MHCC-LM3, MHCC-97L and SK-Hep1 cells. Quantitative results are presented (original magnification: × 200). (c) Knockdown of MDIG (shMDIG-1, -2, -3) suppresses in vitro migration in Huh7 and MHCC-97H cells compared to negative control (NC) and blank cell control (MOCK). Quantitative results are shown (original magnification: × 100). (d) Knockdown of MDIG suppresses in vitro invasion of Huh7 and MHCC-97H cells. Quantitative data are shown (original magnification: × 200). The graph of (a), (b), (c) and (d) are shown as mean±s.d. of n=3 independent experiments. Unpaired Student’s t-tests were used for statistical analysis (*P<0.05, **P<0.01, ***P<0.001)