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. 2018 Oct 18;11:131–142. doi: 10.1016/j.omtm.2018.10.007

Figure 1.

Figure 1

hAAT Inhibited BM cDC Maturation and Expression of Costimulatory Molecules

BM cDCs from B6.TC mice were differentiated in vitro with or without hAAT for 4 days and then stimulated or not with 10 μg/mL CpG for an additional 24 hr prior to fluorescence-activated cell sorting (FACS) analysis. (A) Representative FACS plots showing the MFI (mean fluorescence intensity) of cDC costimulatory molecules CD80, CD86, and MHC-II. (B) Statistical analysis for CD80, CD86, and MHC-II expression on cDCs. (C) IFN-I, TNF-α, IL-12, and IL-6 levels in supernatants. Data were expressed as the mean ± SEM and analyzed by one-way ANOVA using Tukey’s post hoc test corrections. n = 3; *p < 0.05, **p < 0.01, and ***p < 0.001.