Table 1.
Patient demographics and baseline CSF measures
Demographic | EXPEDITION + EXPEDITION2 |
EXPEDITION3 |
||
---|---|---|---|---|
Solanezumab |
Placebo |
Solanezumab |
Placebo |
|
CSF sample (n = 120) | CSF sample (n = 121) | CSF sample (n = 211) | CSF sample (n = 210) | |
Age, years | 71.7 (8.6) | 72.1 (7.45) | 71.4 (7.89) | 71.9 (7.55) |
Female, N (%) | 59 (49.2) | 67 (55.4) | 122 (57.8) | 115 (54.8) |
CSF total Aβ1–40, pg/mL | 10,700 (3460) | 10,800 (4000) | 11,100 (4970) | 10,700 (4320) |
CSF total Aβ1–42, pg/mL | 741 (339) | 698 (326) | 737 (220) | 747 (226) |
CSF free Aβ1–40, pg/mL | 6110 (1810) | 6310 (2030) | 5700 (2030) | 5750 (2030) |
CSF free Aβ1–42, pg/mL | 300 (184) | 289 (158) | 272 (99.3) | 278 (103) |
Abbreviations: Aβ, amyloid β; CSF, cerebrospinal fluid; N, number of patients; n, number of samples; SD, standard deviation.
NOTE. Patient demographics and baseline CSF are for patients with CSF measures. Unless otherwise noted, demographic data are shown as mean (SD).