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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Diabetes. 2018 Mar 21;67(6):1128–1139. doi: 10.2337/db17-1102

Figure 6. The adrenaline effect is attenuated by chronic hyperglycemia.

Figure 6

(a) Typical [Ca2+]i responses to 5μM adrenaline recorded in mouse islet α-cells precultured at 11 mM (n=102) or 30 mM (n=146) glucose for 48 hours. (b) Quantification of the data presented in (a). p<0.05) vs the basal (3 mM glucose) of the same recording (#) or vs the effect of 3 mM glucose + adrenaline in islets pre-cultured in 11 mM glucose (¶). (c) cAMP responses to adrenaline in pancreatic islet α-cells pre-cultured at 11 (n=164) or 30mM (n=212) glucose. (d) PKA responses to adrenaline in pancreatic islet α-cells pre-cultured at 11 (n=1277) or 30 mM (n=1323) glucose. (e) Glucagon secretion from pancreatic islets pre-cultured at 11 (n=10) or 30 mM (n=10) glucose. p<0.05) vs the basal (3 mM glucose) condition (#) or vs the respective effect in islets precultured in 11 mM glucose (¶).