FIG 1.
Brain PrPres signature obtained from coinfection experiments in 129 Ola mice. Western blot images of the PrPres signature displayed by the coinfected wild-type 129 Ola mice and the corresponding controls. (A) Coinfection of 22L and RML. Both strains show an undistinguishable 21-kDa pattern. (B) Coinfection of 22L and BSEm. The only PrPres component in coinoculated animals is the one given by 22L strain, since the Sha31 antibody does not reveal any BSEm pattern (19-kDa band) in the samples. (C) Coinfection of 22L and fast-sCJD. Fast-sCJD is nontransmissible in this animal model, so the PrPres displayed is for the 22L strain.