Table 1.
Antioxidant genes regulated by Nrf2.
| Function | Gene | Species (organs) | Reference |
|---|---|---|---|
| GSH biosynthesis | GCLC | Mouse (liver, lung) Human (HaCaT;keratinocyte) |
[58,67] [68] |
| GCLM | Mouse (liver, lung) Human (IMR-32;neuroblastoma cell) (HaCaT) |
[58,67] [68,69] |
|
| GSR | Mouse (liver, lung) Human (IMR-32, HaCaT) |
[70,71] [68,69] |
|
| Glutathione peroxidases | GPx1 | Mouse (cardiovascular, lung) | [72] |
| GPx2 | Mouse (liver, lung) Rat (liver) Human (Caco-2;colon Cell) Rat (liver) |
[73,74] [75] [76] |
|
| Thioredoxin reductase | TXNRD | Mouse (liver, lung) Human (IMR-32) |
[65,67] [69] |
| Thioredoxin | TXN | Mouse (liver) | [58] |
| Peroxiredoxin | PRDX1 | Mouse (liver,lung) | [67,74] |
| PRDX6 | Human (A549; lung derived cell line) | [77] | |
| Superoxide dismutase | SOD1 | Mouse (liver) | [71] |
| SOD2 | Mouse (liver) | [71] | |
| SOD3 | Mouse (lung) | [67] | |
| Catalase | Mouse (liver, lung) | [71,73] | |
| Glutathione S-transferases | GSTA1 | Mouse (liver, lung, small intestine) | [64,67,71] |
| GSTA2 | Mouse (liver, lung, small intestine) | [58,64,67] | |
| GSTA3 | Mouse (liver, lung, small intestine) | [64,67,71] | |
| GSTA4 | Mouse (liver) | [65] | |
| GSTM1 | Mouse (liver, small intestine) | [58,64,65] | |
| GSTM2 | Mouse (liver, small intestine) | [58,64,65] | |
| GSTM3 | Mouse (liver, small intestine) Human (IMR-32) |
[58,64,65] [69] |
|
| GSTM4 | Mouse (liver) | [65] | |
| GSTM5 | Mouse (liver) | [59] | |
| GSTM6 | Mouse (liver) | [65] | |
| MGST2 | Mouse (small intestine) | [64] | |
| MGST3 | Mouse (liver, small intestine) | [58,64] | |
| UDP-glucuronosyl transferase | UGT1A6 | Mouse (liver) | [74] |
| UGT2B1 | Mouse (liver) | [71] | |
| UGT2B5 | Mouse (liver, small intestine) | [58,64] | |
| Reduction | NQO1 AKR1A AKR1B8 |
Mouse (liver, lung, small intestine) Human (IMR-32) Mouse (liver, small intestine) Mouse (liver, small intestine) |
[58,64,67] [69] [58,64] [64,67] |
| Heme oxygenase-1 | HO-1 | Mouse (liver) Rat (liver) Human (IMR-32, HaCaT) |
[59,76] [68,69] |
| Hydrolysis | EPHX | Mouse (liver, small intestine) | [58,64] |
| Iron transport | Ferritin H | Mouse (lung) Human (HaCaT) |
[73] [68] |
| Ferritin L | Mouse (liver) Human (HaCaT) |
[65] [68] |
|
| Detoxication of heavy metals Transport |
MT І | Mouse (embryonic fibroblasts) Human (HepG2 cell;hepatoma) |
[56] [78] |
| MT ІІ | Mouse (embryonic fibroblasts) Human (HepG2 Cell) |
[56] [78] |
|
| MRP2 | Mouse (liver) | [71] | |
| MRP3 | Mouse (liver) Human (NSCLC, HBE1) |
[71] [79] |
|
| 26S Proteasome | Psma1,4,5,6,7 Psmb1,2,3,4,5,6 |
Mouse (liver) Mouse (liver) |
[58] [58] |
| Psmc1,3 Psmd1,5,7,11,12,13 |
Mouse (liver) Mouse (liver) |
[58] [58] |
|