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. 2010 Dec 6;15(12):8856–8889. doi: 10.3390/molecules15128856

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© 2010 by the authors;

licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

The Plasmodium falciparum MSP-1 antigen, as a model for pseudopeptide and peptido-mimetic designing. A. MSP-1 proteolytic processing to produces a non-covalent complex on the parasite membrane surface during malarial infection of RBCs. B. MSP-1^42–61 N-terminus HABP coded 1513 template sequence, for isoster bond and D-partially substituted analogue design. C. MSP-1^38–58 template sequence and its designed isoster bond analogues. MSP-1^1282–1301 C-terminus sequence HABP coded 1585 template sequence, for isoster bond and D-partially substituted analogue design. Codes for each pseudopeptide were arbitrary assigned to avoid using nomenclature for L- and D- enantiomers. ψ-[CH₂NH] represents a reduced amide isoster bond.