Table 1.
Structures and tumor cytotoxicity of amide derivatives of β-hederin.
 | ||||||
|---|---|---|---|---|---|---|
| Compd. | R1 | IC50 (μM) | ||||
| HeLa | MCF-7 | HL-60 | HT1080 | HepG2 | ||
| TS1 |  |
> 100 | > 100 | 14.46 | > 50 | > 50 |
| TS2 |  |
> 100 | > 100 | 12.78 | > 200 | > 100 |
| TS3 |  |
> 100 | > 100 | 11.53 | > 100 | > 100 |
| TS4 |  |
24.14 | > 100 | > 100 | > 200 | > 100 |
| TS5 |  |
> 100 | 19.72 | > 100 | > 100 | > 100 |
| TS6 |  |
> 100 | 13.80 | > 100 | > 50 | > 50 |
| TS7 |  |
> 100 | > 100 | 15.58 | > 50 | > 50 |
| TS8 |  |
8.80 | 9.89 | > 100 | > 50 | > 50 |
| TS9 |  |
4.74 | 17.13 | > 100 | > 100 | > 100 |
| TS10 |  |
> 100 | > 100 | 18.20 | > 100 | > 100 |
| TS11 |  |
> 200 | > 100 | > 100 | > 100 | > 100 |
| TS12 |  |
> 100 | > 100 | 16.29 | > 100 | > 100 |
| TS13 |  |
18.99 | 14.83 | > 100 | > 50 | > 50 |
| β-hederin |  |
12.47 | 9.53 | 8.26 | > 50 | 19.72 |