. 2011 Jan 14;16(1):552–566. doi: 10.3390/molecules16010552

Table 1.

Half-lives for the partial reactions involved in hydrolysis of thymidine 5´-bis[3-acetyloxy-2-cyano-2-(2-phenylethylcarbamoyl)propyl]phosphate (1) to 5´-TMP at pH 7.5 and 37 °C (I = 0.1 mol L^-1 with NaCl). For the reactions, see Scheme 4. [HLE] = 26 units mL^-1. The corresponding half-lives reported previously [29] for thymidine 5´-bis[3-acetyloxymethoxy-2,2-bis(ethoxycarbonyl)propyl]phosphate (2) and thymidine 5´-bis[3-acetyloxy-2,2-bis(ethoxycarbonyl)propyl]phosphate (3) are included for reference.

	t_1/2/ min
Reaction	1	2	3
A	3.8	0.17	3.2
D	2838	210	9060
B	≈ 2	0.90	31^a
C	≈ 0.2	10.4	31^a

^a 25 °C.