Table 2.
Cytotoxicity (IC50 values, µM) of the compounds 1-5, 7-16, 18-20.
| Compound | Cytotoxicitya IC50 (µM)b | ||
|---|---|---|---|
| MRC-5 | AGS | Hep G2 | |
| 1 | 447 ± 26 | 189 ± 9 | 242 ± 13 |
| 2 | > 1,000 | > 1,000 | > 1,000 |
| 3 | > 1,000 | 445 ± 27 | 806 ± 32 |
| 4 | 288 ± 11 | 167 ± 7 | 321 ± 14 |
| 5 | 260 ± 15 | 149 ± 7 | 291 ± 11 |
| 7 | 459 ± 32 | 266 ± 16 | 364 ± 15 |
| 8 | 890 ± 45 | 592 ± 30 | 841 ± 42 |
| 9 | 119 ± 7 | 82 ± 4 | 67 ± 3 |
| 10 | > 1,000 | > 1,000 | > 1,000 |
| 11 | > 1,000 | 361 ± 18 | 541 ± 22 |
| 12 | 380 ± 19 | 309 ± 18 | 673 ± 34 |
| 13 | 449 ± 29 | 308 ± 17 | 808 ± 48 |
| 14 | > 1,000 | 297 ± 14 | 894 ± 56 |
| 15 | > 1,000 | > 1,000 | > 1,000 |
| 16 | > 1,000 | 483 ± 29 | 529 ± 36 |
| 18 | 495 ± 35 | > 1000 | > 1000 |
| 19 | 267 ± 14 | 206 ± 10 | 316 ± 16 |
| 20 | > 1,000 | > 1,000 | > 1,000 |
| Lansoprazole | 306 ± 11 | 162 ± 6 | 221 ± 9 |
a Cultured human cell lines: MRC-5, human normal lung fibroblasts; AGS, gastric epithelial adenocarcinoma cells; Hep G2, hepatocytes. b Values are arithmetic means of three different experiments in quadruplicate ± SD. Confluent cultures were treated with the culture medium containing the compounds at concentrations ranging between 0 and 1000 µM for 24 h. Cell viability was determined by the neutral red uptake assay. c Lansoprazole was used as the reference drug.