Table 2.
Test–retest reproducibility of kinetic parameters of [11C]UCB-J derived with 1T model from 120 min of TACs.
|
K1
(mL/cm3 per min) |
VT
(mL/cm3) |
VT/fp
(mL/cm3) |
||||
|---|---|---|---|---|---|---|
| Region | aTRV | TRV | aTRV | TRV | aTRV | TRV |
| Putamen | 4% | 2% ± 5% | 5% | 0% ± 6% | 7% | 0% ± 9% |
| Temporal cortex | 7% | 2% ± 10% | 4% | −1% ± 5% | 6% | −1% ± 7% |
| Insular cortex | 8% | −3% ± 9% | 5% | −1% ± 6% | 7% | −1% ± 9% |
| Ant. cingulate cortex | 4% | 0% ± 6% | 5% | 0% ± 6% | 6% | 0% ± 7% |
| Amygdala | 9% | −3% ± 11% | 9% | −2% ± 14% | 12% | −3% ± 16% |
| Parietal cortex | 5% | −1% ± 7% | 4% | −1% ± 5% | 5% | −1% ± 6% |
| Occipital cortex | 8% | −2% ± 11% | 4% | −1% ± 5% | 5% | −2% ± 6% |
| Caudate nucleus | 4% | 3% ± 4% | 4% | −1% ± 6% | 7% | −1% ± 9% |
| Frontal cortex | 4% | 2% ± 7% | 3% | 1% ± 4% | 5% | 0% ± 6% |
| Globus pallidus | 3% | 0% ± 4% | 7% | −4% ± 8% | 9% | −4% ± 10% |
| Thalamus | 7% | 7% ± 7% | 3% | 2% ± 4% | 6% | 1% ± 7% |
| Cerebellum | 3% | 1% ± 4% | 3% | 1% ± 3% | 6% | 1% ± 7% |
| Hippocampus | 5% | −1% ± 7% | 4% | −1% ± 6% | 8% | −1% ± 9% |
| Post. cingulate cortex | 6% | 3% ± 7% | 3% | −1% ± 3% | 6% | −1% ± 7% |
| Centrum semiovale | 6% | −1% ± 8% | 3% | −1% ± 5% | 7% | −2% ± 9% |
Note: Data are mean ± SD. Ant.: anterior; aTRV: absolute test–retest variability; Post.: posterior; TRV: test–retest variability; 1T: 1-tissue compartment model; TAC: time activity curve.