. 2018 Sep 5;38(11):1853–1871. doi: 10.1177/0271678X18797958

Table 5.

Spontaneous intracerebral hemorrhage.

Study	Country(ies) of study	Patients/ controls	Gene	Relevant function	Reference SNP #	Amino acid change	Common name	Associated population	Inheritance model	OR	CI at 95%	p
Variants associated witd spontaneous intracerebral hemorrhage
Chen and Hu²¹	China	2018/2143	APOE	Plasma lipid modulation	rs429358	130C > R	ɛ4	Chinese	Dominant	2.41	1.68–3.47	0
Chen and Hu²¹	China	2018/2143	APOE	Plasma lipid modulation	rs429358	130C > R	ɛ4	Chinese	Additive	2.08	1.57–2.75	0
Yamada et al.²⁸	Japan	673/9158	STYK1	Endothelial and vascular health	rs138533962	379R > C		Japanese	Dominant	111.3	33.0–694.6	<0.001
Gao et al.⁷²	China, India, Japan, Turkey	1828/4067	MTHFR	Endothelial and vascular health (homocysteine metabolism)	rs1801133	229A > V	677C > T	Multiethnic	Dominant	1.41	1.12–1.78	0.003
									Recessive	1.9	1.42–2.55	<0.001
									Allelic	1.38	1.17–1.62	<0.001
Variants associated with lobar intracerebral hemorrhage
Biffi et al.⁷¹	Austria, Poland, Sweden, USA	931/3744	APOE	Plasma lipid modulation	rs7412	176R > C	ɛ2	Caucasian	Allelic	1.82	1.50–2.23	<0.001
Biffi et al.⁷¹	Austria, Poland, Sweden, USA	931/3744	APOE	Plasma lipid modulation	rs429358	130C > R	ɛ4	Caucasian	Allelic	2.2	1.85–2.63	<0.001
Variants associated with deep intracerebral hemorrhage
Biffi et al. ⁷¹	Austria, Poland, Sweden, USA	1085/3657	APOE	Plasma lipid modulation	rs429358	130C > R	ɛ4	Caucasian	Allelic	1.21	1.08–1.36	0.00026