Table 1.
Participants’ demographics and PET parameters (mean ± SD).
| HV (n = 14) | aMCI (n = 11) | ||
|---|---|---|---|
| Age (years) | 67.07 ± 6.49 | 71.91 ± 5.30 | t = 1.59, p = 0.13 |
| Gender | |||
| Female | 9 | 6 | χ2 = 0.24, p = 0.62 |
| Male | 5 | 5 | |
| Education (years) | 16.21 ± 3.40 | 15.82 ± 2.36 | t = −0.33, p = 0.75 |
| MMSE | 29.3 ± 1.25 | 27.3 ± 1.95* | t = −2.80, p = 0.01 |
| MoCA | 27.0 ± 1.4 | 21.7 ± 3.6* | t = −4.63, p = 0.001 |
| Concurrent | |||
| Cholinesterase inhibitors | 0 | 2 | |
| Medications | |||
| Antihypertensives | 1 | 5 | |
| Statins | 1 | 3 | |
| Antidepressants | 0 | 6 | |
| Baby aspirin | 1 | 1 | |
| [18F]-FEPPA | |||
| Amount injected (mCi) | 4.99 ± 0.25 | 4.81 ± 0.56 | t = −1.04, p = 0.31 |
| Specific activity (mCi/µmol) | 2868.56 ± 2120.49 | 1960.49 ± 1481.40 | t = −1.21, p = 0.24 |
| Mass injected (µg) | 1.22 ± 1.16 | 1.42 ± 0.83 | t = 0.48, p = 0.64 |
| [11C]-PIB | |||
| Amount injected (mCi) | 9.47 ± 1.04 | 9.87 ± 0.66 | t = 1.18, p = 0.25 |
| Specific activity (mCi/µmol) | 1892.86 ± 1029.12 | 2135.01 ± 1122.85 | t = 0.56, p = 0.58 |
| Mass injected (µg) | 1.90 ± 1.07 | 1.43 ± 0.59 | t = −1.30, p = 0.21 |
aMCI: amnestic mild cognitive impairment; HV: healthy volunteer; MMSE: mini-mental state examination; MoCA: Montreal cognitive assessment; SD: standard deviation.