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. 2018 Nov 4;46(11):4760–4768. doi: 10.1177/0300060517754026

Table 2.

Previous case reports of EAS that developed after diagnosis of ONB.

Patient Age (years) Sex Time from onset of ONB to diagnosis of EAS Symptoms ACTH(pmol/L) Cortisol(nmol/L) Urinary cortisol(nmol/day) Treatment for ONB Relapse of ONB Ref.
1 70 Male 15 years Fatigue, confusion, severe hypertension, muscle atrophy, hyperglycemia, hypokalemia, metabolic alkalosis 100.1 2428.8 42,120 Craniotomy Yes [2]
2 66 Female 2 years Systemic edema, fatigue, moon face, truncal obesity, thin skin with purpura and hirsutism, hypokalemia, metabolic alkalosis 189.6 1802.2 13,924 Refused craniotomy Yes [3]
3 48 Female 28 months Cushing like-syndrome (details unknown) Craniotomy Yes [4]
4 50 Male 4 years Moon face, truncal obesity, purpura, muscle atrophy, hypertension, hyperglycemia, hypokalemia, metabolic alkalosis 39.3 2461.9 28,428 Radiation and chemotherapy Yes Present case

EAS, ectopic adrenocorticotropic hormone syndrome; ACTH, adrenocorticotropic hormone; ONB, olfactory neuroblastoma.