Table 2.
Patient | Age (years) | Sex | Time from onset of ONB to diagnosis of EAS | Symptoms | ACTH(pmol/L) | Cortisol(nmol/L) | Urinary cortisol(nmol/day) | Treatment for ONB | Relapse of ONB | Ref. |
---|---|---|---|---|---|---|---|---|---|---|
1 | 70 | Male | 15 years | Fatigue, confusion, severe hypertension, muscle atrophy, hyperglycemia, hypokalemia, metabolic alkalosis | 100.1 | 2428.8 | 42,120 | Craniotomy | Yes | [2] |
2 | 66 | Female | 2 years | Systemic edema, fatigue, moon face, truncal obesity, thin skin with purpura and hirsutism, hypokalemia, metabolic alkalosis | 189.6 | 1802.2 | 13,924 | Refused craniotomy | Yes | [3] |
3 | 48 | Female | 28 months | Cushing like-syndrome (details unknown) | – | – | – | Craniotomy | Yes | [4] |
4 | 50 | Male | 4 years | Moon face, truncal obesity, purpura, muscle atrophy, hypertension, hyperglycemia, hypokalemia, metabolic alkalosis | 39.3 | 2461.9 | 28,428 | Radiation and chemotherapy | Yes | Present case |
EAS, ectopic adrenocorticotropic hormone syndrome; ACTH, adrenocorticotropic hormone; ONB, olfactory neuroblastoma.