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IC50 values of compounds 1-5 tested against FcB1 strain of P. falciparum and MRC-5 cell.
| Compound | IC50 P.f. FcB1 (µM) ± SD (n=3) | IC50 MRC-5 (µM) ± SD (n=3) |
|---|---|---|
| 1 | 10.5a | 36a |
| 2 | 15.1a | b |
| 3 | 11.4a | 29a |
| 4 | 3.5 ± 1.1 | 3.5 ± 0.4 |
| 5 | 3.2 ± 1.3 | 2.3 ± 0.5 |
| Chloroquine | 0.078 ± 0.006 | |
| Taxotere | 31.5 ± 4.5 |
a biological assays in duplicates; b not enough material.
