Table 2.
Percentage inhibition of isolated compound of Mitrphora vulpina and aspirin on platelet aggregation of human whole blood induced by AA (0.5 mM), collagen (2 μg/mL) and ADP (10 μM) and their IC50 values.
| Sample | µg/mL | Inhibition % | ||
|---|---|---|---|---|
| AA | ADP | Collagen | ||
| Oxoputerine | 100 | 6.57 ± 2.0 | 11.3 ± 1.1 | 25.2 ± 3.8 |
| Liriodenine | 100 | 38.9 ± 7.1 | 30.1 ± 7.1* | 29.4 ± 2.5 |
| Stigmasterol | 100 | 25.7 ± 0.3 | 24.8 ± 0.2 | 8.2 ± 3.3 |
| Phylligenin | 100 | 51.2 ± 1.7* | 66.1 ± 7.0* | 22.1 ± 3.8 |
| 50 | 43.6 ± 4.6 | 50.8 ± 1.7 | ||
| 25 | 29.5 ± 6.6 | 39.9 ± 6.1 | ||
| 12.5 | 20.7 ± 0.3 (230.6 ± 0.4) | 24.7 ± 1.5 (121.8 ± 5.7) | ||
| Quebrachitol | 100 | 10.3 ± 2.0 | 3.3 ± 0.9 | 11.8 ± 4.1 |
| Acetylsalicylic acid | 25 | 99.7 ± 0.3* | 48.8 ± 8.7* | 35.2 ± 4.3* |
| 12.5 | 79.4 ± 2.8 | |||
| 6.25 | 62.4 ± 5.3 | |||
| 3.13 | 51.8 ± 3.8 | |||
| 1.5 | 30.7 ± 0.0(24.8 ± 4.5) | |||
Values are presented as means ± SD (n = 3). *P < 0.05 as compared with control. IC50 values in µM are presented in parentheses.