. 2010 Oct 28;15(11):7699–7714. doi: 10.3390/molecules15117699

Table 1.

Effects of different selenium compounds on DTT oxidation.

	0 min (nmol -SH/mL)	60 min (nmol -SH/mL)	(%) -SH oxidation)
Control	43.48 ± 0.24	30.62 ± 0.25^a	29.57
I—Diphenyl diselenide		5.82 ± 0.27^e	86.61
II—Bistrifluoromethyl-		23.37 ± 0.36^c	46.25
III—Bismethoxy-		36.46 ± 0.83^f	16.14
IV—Biscarboxy-		47.19 ± 0.32^h	0.0
V—Bischloro-		17.88 ± 0.26^d	58.87
VI—Hexamethyl-		28.00 ± 0.40^b	35.60
VII—Ebselen		29.51 ± 0.27^a,b	32.12

Values represent mean ± s.e. from three independent experiments performed in duplicate. Selenium compounds were tested at 0.1 mM [(i) diphenyl diselenide, (ii) bistrifluoromethyl-diphenyl diselenide, (iii) bismethoxydiphenyl diselenide, (iv) biscarboxydiphenyl diselenide, (v) bischlorodiphenyl diselenide, (vi) hexamethyldiphenyl diselenide and (vii) ebselen]. Reaction was started by adding DTT (to a final concentration of 0.5 mM) and then, aliquots (100 μL) were sampled immediately or 60 min after mixing DTT with compounds. Statistical analysis was performed by One-way ANOVA followed by Duncan´s multiple range test. Means that do not share the same superscript letter are different (p < 0.05).