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. 2018 Nov 27;7:F1000 Faculty Rev-1851. [Version 1] doi: 10.12688/f1000research.16434.1

Figure 2. “Side view” of the open RyR1 channel structure 9.

Figure 2.

The structure (PDB code 5TAL) reveals the major domains of the protein and the location of Ca 2+, ATP, and caffeine binding sites identified by 13. Adapted from 17; the structural domain nomenclature is as given in 10. The transmembrane domain (TMD) containing the permeation pathway is shown embedded in the sarcoplasmic reticulum (SR) membrane, which is depicted as a solid pale blue rectangle. NTD, N-terminal domain; RyR, ryanodine receptor.