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Pancreatic lipase inhibitory activity of compounds 1–9.
| Compound | IC50a (μM) | Compound | IC50a (μM) |
|---|---|---|---|
| 1 | 50.5 ± 3.9 | 6 | >200 |
| 2 | 31.6 ± 2.7 | 7 | >200 |
| 3 | 44.6 ± 1.3 | 8 | 33.6 ± 2.0 |
| 4 | 25.9 ± 3.7 | 9 | >200 |
| 5 | 18.5 ± 2.6 | Orlistat b | 0.3 ± 0.2 |
a IC50 values of compounds represent the concentration that caused a 50% reduction in enzyme activity. Inhibitory effects are expressed as the mean ± S.D. of quadruplicate experiments; b Orlistat was used as a positive control.
