Table 2.

Central analgesic activity (Hot plate test).

Group	Reaction time (min)
	0 min	30 min	60 min	90 min
Control	8.25 ± 0.35	8.20 ± 0.36 b	8.75 ± 0.55 b	9.80 ± 0.48 b
Visnagen	5.40 ± 0.56	6.30 ± 0.50	8.90 ± 0.60	9.80 ± 0.25 a
Khellin	5.50 ± 0.58	6.50 ± 0.40	9.01 ± 0.70	10.01 ± 0.22 a
1a	5.60 ± 0.30	6.70± 0.43	9.25 ± 0.55	10.10 ± 0.20a
1b	6.10 ± 0.20	7.30 ± 0.10 b	7.40 ± 0.10 a	10.20 ± 0.25 a
2a	6.20 ± 0.10	7.45 ± 0.20 b	8.10± 0.20 a	10.50 ± 0.30 a
2b	6.40 ± 0.20	7.55 ± 0.25 b	8.25± 0.30 a	10.80 ± 0.35 a
3a	7.01 ± 0.30	8.10 ± 0.40	10.55 ± 0.50 a	10.90 ± 0.60 a b
3b	6.65 ± 0.10	7.90 ± 0.20 b	8.45 ± 0.50 a	11.20 ± 0.30 a
3c	7.10 ± 0.10	8.20 ± 0.30 a	9.50 ± 0.25 a	10.55 ± 0.10 a b
3d	6.65 ± 0.10	7.90 ± 0.20 b	8.45 ± 0.50 a	11.20 ± 0.30 a
4a	7.85 ± 0.35	8.60 ± 0.40 a	10.01 ± 0.20a	11.05± 0.40 a b
4b	7.30 ± 0.20	8.30 ± 0.40 a	9.80 ± 0.30 a	10.80 ± 0.20 a b
4c	8.10 ± 0.20	8.80 ± 0.25 a	10.10 ± 0.25 a	11.10 ± 0.30 b
4d	7.40 ± 0.30	8.50 ± 0.30 a	9.90 ± 0.35 a	10.90 ± 0.30 a b
5a	8.75 ± 0.60	9.10 ± 0.50 a	10.70 ± 0.40 a	11.50 ± 0.40 b
5b	8.30 ± 0.30	8.90 ± 0.30 a	10.30 ± 0.20 a	11.20 ± 0.25 b
5c	8.95 ± 0.68	9.20 ± 0.60 a	10.90 ± 0.50 a	11.60 ± 0.30 b
5d	8.55 ± 0.50	9.01 ± 0.40 a	10.50 ± 0.30 a	11.40 ± 0.30 b
6a	9.30 ± 0.30	9.40 ± 0.30 a	10.40 ± 0.25 a	11.10± 0.30 a b
6b	9.10 ± 0.30	9.20 ± 0.40 a	10.20 ± 0.20 a	11.10 ± 0.40a b
6c	9.40 ± 0.40	9.50 ± 0.30 a	10.50 ± 0.20 a	11.20± 0.35 a b
6d	9.20 ± 0.20	9.30 ± 0.10 a	10.30 ± 0.30 a	11.01± 0.20 a b
7a	9.70 ± 0.40	9.80 ± 0.55 a	10.75 ± 0.35 a	11.44± 0.44 a b
7b	9.50 ± 0.20	9.60 ± 0.40 a	10.60 ± 0.25 a	11.30± 0.30 a b
7c	9.80 ± 0.50	9.95 ± 0.65 a	10.85 ± 0.45 a	11.98 ± 0.88 a b
7d	9.60 ± 0.30	9.70 ± 0.45 a	10.65 ± 0.30 a	11.40± 0.40 a b
Diclofanc sodium	6.50 ± 0.45	10.05 ± 0.15 a	11.40 ± 0.55 a	13.18 ± 0.40 a

Values represent the mean ± S.E. of six animals for each groups. a. P < 0.05: Statistically significant from Control. (Dunnett’s test). b. P < 0.05: Statistically significant from ASA. (Dunnett’s test).* Significant at P < 0.0.